Thursday, September 20, 2012
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Mouse and patient studies
suggest inhibiting SMO to reduce hedgehog pathway signaling could help
prevent or treat sclerodermatous GvHD. In patients with sclerodermatous GvHD,
hedgehog pathway signaling was greater than that in healthy controls. In a
mouse model of sclerodermatous GvHD, a SMO inhibitor prevented disease onset and
blocked progression of established disease, whereas an inactive control
treatment did not. Next steps include testing the effects of SMO inhibition
in preclinical models of other types of GvHD.
a small molecule SMO inhibitor from Roche,
Inc. unit, Chugai
Pharmaceutical Co. Ltd. and Curis
Inc., is marketed to treat basal cell carcinoma (BCC).
a SMO inhibitor from Novartis
AG, is in Phase III testing to treat BCC.
At least four other companies have SMO inhibitors in Phase I testing or
earlier to treat various cancers.
Published online Sept. 20, 2012
Patent application filed;
licensing status unavailable
Zerr, P. et al. Blood;
published online Aug. 22, 2012;
Contact: Jörg H.W. Distler,
University of Erlangen-Nuremberg, Nuremberg, Germany
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