Thursday, September 20, 2012
Publication and contact
Mouse and patient studies
suggest inhibiting SMO to reduce hedgehog pathway signaling could help
prevent or treat sclerodermatous GvHD. In patients with sclerodermatous GvHD,
hedgehog pathway signaling was greater than that in healthy controls. In a
mouse model of sclerodermatous GvHD, a SMO inhibitor prevented disease onset and
blocked progression of established disease, whereas an inactive control
treatment did not. Next steps include testing the effects of SMO inhibition
in preclinical models of other types of GvHD.
a small molecule SMO inhibitor from Roche,
Inc. unit, Chugai
Pharmaceutical Co. Ltd. and Curis
Inc., is marketed to treat basal cell carcinoma (BCC).
a SMO inhibitor from Novartis
AG, is in Phase III testing to treat BCC.
At least four other companies have SMO inhibitors in Phase I testing or
earlier to treat various cancers.
Published online Sept. 20, 2012
Patent application filed;
licensing status unavailable
Zerr, P. et al. Blood;
published online Aug. 22, 2012;
Contact: Jörg H.W. Distler,
University of Erlangen-Nuremberg, Nuremberg, Germany
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]