Thursday, September 20, 2012
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Protein kinase Cb (PRKCB)
mouse studies suggest PRKCB inhibitors could help treat Ewing's sarcoma.
PRKCB was overexpressed in primary Ewing's sarcomas compared with primary
medulloblastomas and other pediatric tumor types. In Ewing's sarcoma cell
lines, PRKCB small hairpin RNA or enzastaurin decreased proliferation
and survival compared with scrambled control shRNA or vehicle. In mice with
xenograft Ewing's sarcoma tumors, PRKCB shRNA or enzastaurin decreased
tumor volume compared with scrambled control shRNA or vehicle. Next steps
could include testing PRKCB inhibition in animal models of metastatic Ewing's
a synthetic PRKCB inhibitor from Eli
Lilly and Co., is in registration to treat diabetic
an inhibitor of PRKCB and protein
kinase B (PKB;
from Eli Lilly, is in Phase III
testing to treat B cell lymphoma.
Published online Sept. 20, 2012
Patent and licensing status
Surdez, D. et al. Cancer
published online Aug. 30, 2012;
Contact: Franck Tirode, Curie Institute, Paris, France
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