Thursday, September 20, 2012
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Multiple myeloma (MM)
Ubiquitin specific peptidase 7 (USP7;
In vitro and mouse studies suggest the USP7 inhibitor P5091
could help treat MM. In primary MM tumors, USP7 expression was greater than
that in healthy tissues and correlated with poor survival. In MM cell lines
and primary tumor cells, including those resistant to Velcade
P5091 decreased cell viability compared with vehicle and/or Velcade. In three
mouse models of MM, P5091 decreased tumor growth and increased survival
compared with vehicle. Progenra
Inc. participated in the study, and ongoing work at the
company includes undisclosed preclinical studies of P5091 and its analogs.
Pharmaceutical Co. Ltd.'s Millennium
Pharmaceuticals Inc. unit and Johnson
& Johnson market Velcade, a small molecule dipeptide
boronic acid proteasome inhibitor, to treat MM and mantle cell lymphoma
S.A. has two USP7 inhibitors, HBX 19,818
and HBX 41,108,
in preclinical development for chronic lymphocytic leukemia (CLL) and cancer,
Published online Sept. 20, 2012
Patent status undisclosed;
available for licensing or partnering
Chauhan, D. et al.
Cancer Cell; published online Sept. 11, 2012;
Contact: Kenneth C. Anderson,
Dana-Farber Cancer Institute, Boston, Mass.
Contact: Dharminder Chauhan,
same affiliation as above
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