BioCentury
ARTICLE | Distillery Techniques

Techniques: Knock-in mouse model of Niemann-Pick disease type C1 (NPC1)

June 11, 2015 7:00 AM UTC

Transgenic mice with a knock-in mutation of human NCP1 could be useful for screening therapies to treat Niemann-Pick disease type C1. The most common NCP1 mutation in the disease, I1061T, encodes an u...