BioCentury
ARTICLE | Distillery Techniques

Techniques: N-terminal-specific conjugation of proteins via reaction with 2-pyridinecarboxyaldehydes (2PCA)

April 23, 2015 7:00 AM UTC

A one-step chemical reaction with 2PCA could enable N-terminal-specific conjugation of polyethylene glycol (PEG), biotin and other molecules to biologically active proteins. In vitro studies showed 2P...