BioCentury
ARTICLE | Distillery Techniques

Techniques: CRISPR-Cas9 genome editing to generate colon cancer organoid models

March 19, 2015 7:00 AM UTC

In vitro studies suggest intestinal epithelial organoids with CRISPR-Cas9-edited genomes could model human colon cancer. Single human intestinal stem cells were engineered to express combinations of m...