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Noninvasive MRI signature for predicting epilepsy

A noninvasive MRI-based approach could help predict epilepsy. In rats, decreased MRI T2 relaxation times in the amygdala two hours after induction of febrile status epilepticus predicted the subsequent development of temporal lobe epilepsy with high sensitivity and specificity compared with what was seen in normal controls. The decreased T2 relaxation times were associated with increased deoxyhemoglobin levels, suggesting elevated oxygen use in the brain following febrile status epilepticus. Next steps include validating the predictive marker in humans.

SciBX 7(29); doi:10.1038/scibx.2014.880
Published online July 31, 2014

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Choy, M. et al. J. Neurosci.; published online June 25, 2014;
Contact: Tallie Z. Baram, University of California, Irvine, Calif.