Thursday, July 31, 2014
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Extending liver storage
time from 12 hours to 3 days before transplant with supercooling and machine
Rat studies suggest machine
perfusion and supercooling can extend the
ex vivo life of livers for transplant. In the method, isolated livers
were loaded with a solution containing a nonmetabolized glucose derivative
via machine perfusion, cooled to 4° C, flushed with and immersed in University
of Wisconsin preservation solution containing 5% polyethylene glycol and then
slowly supercooled to -6° C. In transplant experiments, rats receiving livers
that were machine perfused and supercooled for 72 or 96 hours survived for at
least 3 months, whereas all rats receiving livers preserved for 72 hours by
standard hypothermic methods died from liver failure within 2 days. Next
steps include applying the procedure in pigs.
Published online July 31, 2014
Patent applications filed
covering supercooling preservation, machine perfusion recovery and quality
assessment; technology will be licensed to Organ
Berendsen, T.A. et al.
Nat. Med.; published online June 29, 2014; doi:10.1038/nm.3588
Contact: Korkut Uygun, Harvard Medical School, Boston, Mass.
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