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Disease models

Pigtailed macaque model of AIDS

Monkey studies suggest pigtailed macaques that lack an HIV-1 restricting protein, tripartite motif-containing 5 (TRIM5), could be used as a primate model of AIDS. An HIV-1 clone, which attaches to cells through CC chemokine receptor 5 (CCR5; CD195) and encodes the simian immunodeficiency virus's virion infectivity factor (Vif), was used to infect pigtailed macaques that were transiently depleted of CD8+ T cells. The virus was then serially propagated in five subsequent groups of monkeys, in which it gained the ability to replicate to higher levels and resulted in CD4+ T cell depletion and clinical features associated with AIDS. Also in the macaques, CD8+ T cell depletion during acute virus infection led to rapid progression to AIDS. Next steps could include validating the macaque model with known HIV-1 therapies and using it to evaluate new prevention and eradication strategies.

SciBX 7(29); doi:10.1038/scibx.2014.877
Published online July 31, 2014

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Hatziioannou, T. et al. Science; published online June 20, 2014;
Contact: Paul D. Bieniasz, Aaron Diamond AIDS Research Center,
New York, N.Y.

Contact: Theodora Hatziioannou, same affiliation as above

Contact: Jeffrey D. Lifson, Frederick National Laboratory, Frederick, Md.

Contact: Vineet N. KewalRamani, National Cancer Institute, Frederick, Md.