Thursday, July 24, 2014
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Assays & screens
Assessing circulating donor
cell-free DNA levels to predict heart transplant rejection
The ratio of circulating
donor cell-free DNA to total cell-free DNA could be used to predict heart
transplant rejection. Circulating cell-free DNA was sequenced from multiple
plasma samples from 65 patients taken before transplantation and at various
time points after transplantation. In samples collected at least two weeks
after transplant, high ratios of circulating donor to overall circulating
cell-free DNA levels correlated with increased risk of transplant rejection.
In the patient samples, elevated donor cell-free DNA levels were detected up
to five months before transplant rejection. Next steps could include
validating the screening method in additional patients.
offers the AlloMap
molecular expression test to monitor heart transplant recipients for a
rejection response. The company is developing a cell-free DNA test to predict
rejection in heart transplant recipients.
Published online July 24, 2014
licensed to CareDx
De Vlaminck, I. et al.
Sci. Transl. Med.; published online June 18, 2014;
Contact: Kiran K. Khush, Stanford University, Stanford,
Contact: Stephen R. Quake, same affiliation as above
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