Thursday, July 17, 2014
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expression to predict antidepressant treatment response
Cell culture and patient
sample studies suggest monitoring miR-1202 expression could help predict
response to antidepressants in patients with depression. In human prefrontal
cortex samples, miR-1202 levels were lower in patients with depression than
healthy controls. In human neural progenitor cells, chronic treatment with
the marketed antidepressants imipramine or Celexa
increased miR-1202 levels compared with no treatment. In blood samples from
patients with depression, miR-1202 expression was lower in remitter patients
than nonresponders and controls, and miR-1202 levels were higher in patients
after Celexa treatment than before treatment. Next steps could include
testing correlations of miR-1202 with other antidepressants and in wider
Imipramine is a generic tricyclic antidepressant.
Citalopram is a generic selective serotonin reuptake inhibitor and is
marketed by H.
Lundbeck A/S and Actavis
plc as Celexa.
Published online July 17, 2014
Patent and licensing status
Lopez, J.P. et al. Nat.
published online June 8, 2014;
Contact: Gustavo Turecki, McGill University, Montreal, Quebec,
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