Thursday, July 17, 2014
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indicators of drugs (LUCIDs) for point-of-care monitoring
A luciferase-based assay
could be used to quickly and quantitatively assess drug concentrations in
patient samples. LUCIDs have three components: a receptor protein that binds
the drug of interest, a luciferase and a synthetic molecule containing a
fluorophore that is coupled to a ligand that also binds the receptor. The
drug concentration can be calculated using the ratio of the luciferase signal
to the fluorophore signal, which is enhanced when the ligand binds the
receptor and is reduced when the drug displaces the ligand. In patient sera
samples, individual LUCIDs designed to detect six different drugs quantified
drug levels based on titrated emission data collected with a digital camera.
Next steps include developing test strips and a handheld reader device to
assess drug concentrations from a drop of blood.
Published online July 17, 2014
Patent application filed
covering the LUCID technology; unavailable for licensing
Griss, R. et al. Nat.
Chem. Biol.; published online June 8, 2014;
Contact: Kai Johnsson, Swiss Federal Institute of Technology
Lausanne, Lausanne, Switzerland
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