Thursday, July 17, 2014
Publication and contact
Depletion of host
hematopoietic stem cells (HSCs) in utero improves engraftment after
liver mononuclear cell transplant in fetuses
Mouse studies suggest in
utero depletion of HSCs can improve engraftment after liver mononuclear
cell transplant. In fetal mice, a mouse anti-stem cell
factor receptor tyrosine kinase (c-Kit;
antibody was shown to deplete HSCs. In fetal mice, depletion of HSCs with the
mouse antibody prior to congenic liver mononuclear cell transplantation
increased the rate and level of donor cell engraftment compared with no
depletion. Next steps include using a humanized version of the antibody in in
utero nonhuman primate bone marrow transplant models of
hemoglobinopathies, such as thalassemia or sickle cell disease.
Published online July 17, 2014
Patent and licensing status
Derderian, S.C. et al.
published online May 30, 2014;
Contact: Tippi C. MacKenzie, University of California,
San Francisco, Calif.
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