Thursday, July 17, 2014
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Assays & screens
In vivo infection system to predict epidemic variants of
mosquito-borne RNA viruses
Mosquito and mouse studies
suggest deep sequencing of saliva can help predict arbovirus strains that
could become epidemic. In Aedes albopictus mosquitoes that carried a
pre-epidemic strain of chikungunya virus, deep sequencing of saliva samples
was used to detect the emergence of a mutation that results in an epidemic
strain. In a prospective analysis of the virus, the epidemic strain acquired
two additional mutations. In A. albopictus, the new viral strain had
greater infection and dissemination titers than the parental strain. Next
steps include applying the method to the chikungunya virus currently
spreading in the Caribbean region and adapting the method for use against influenza
Published online July 17, 2014
status not applicable
Stapleford, K.A. et al.
Cell Host Microbe; published online
June 11, 2014;
Contact: Marco Vignuzzi, Centre National de la Recherche
Scientifique (CNRS) UMR 3569, Paris, France
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