Thursday, June 19, 2014
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Raman scattering (hsSRS) to image drug interactions in live cells
Cell culture studies
suggest the hsSRS imaging approach can be used to study drug-drug
interactions in cells. In cultured cell lines, hsSRS revealed that the BCR-ABL
tyrosine kinase inhibitors Gleevec
accumulated in lysosomes, with nilotinib showing 80 higher accumulation than
predicted values based on the drug's chemical properties. In imatinib-treated
cell lines, hsSRS imaging data suggested chloroquine
could improve the efficacy of imatinib by increasing the cytosolic
availability of the cancer drug. Next steps could include improving the
sensitivity of the technique so less potent drugs can be studied.
Gleevec and Tasigna are marketed by Novartis AG to treat various
Chloroquine is a generic drug used to treat malaria.
Published online June 19, 2014
Patent and licensing status
Fu, D. et al. Nat. Chem.;
published online May 25, 2014;
Contact: X. Sunney Xie, Harvard University, Cambridge, Mass.
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