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Disease models

Mouse model of Crohn's disease

Mice with the T300A mutation in autophagy related 16-like 1 (Atg16l1) could be useful as a model for studying the biology of Crohn's disease and evaluating therapeutic candidates. In the mouse model, knock-in of a Crohn's disease-associated T300A Atg16l1 variant resulted in abnormal intestinal cell morphology and impaired autophagy and led to greater intestinal bacterial replication and higher proinflammatory cytokine production than expression of wild-type Atg16l1. Next steps could include identifying conditions that lead to Crohn's disease pathogenesis in the model.

SciBX 7(24); doi:10.1038/scibx.2014.720
Published online June 19, 2014

Patent and licensing status undisclosed

Lassen, K.G. et al. Proc. Natl. Acad. Sci. USA; published online May 12, 2014;
Contact: Ramnik J. Xavier, Broad Institute of MIT and Harvard, Cambridge, Mass.
Contact: Stuart L. Schreiber, same affiliation as above