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Dipeptidyl peptidase-4 (DPP-4; CD26) as a marker of chronic myelogenous leukemia (CML) stem cells

DPP-4 could be useful as a marker for detecting CML stem cells. In a leukemia stem cell-enriched cellular fraction from patients with CML, gene array and PCR analyses showed that DPP-4 expression was almost entirely restricted to the leukemia stem cell population. Almost 100% of the DPP-4+ cells isolated from this population expressed the oncogenic BCR-ABL tyrosine kinase fusion protein versus none of the DPP-4- cells. Next steps could include validating DPP-4 as a selective and specific marker for CML stem cells in larger patient cohorts.

SciBX 7(23); doi:10.1038/scibx.2014.690
Published online June 12, 2014

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Herrmann, H. et al. Blood; published online April 28, 2014;
Contact: Peter Valent, Medical University of Vienna, Vienna, Austria