Thursday, June 12, 2014
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nanoparticles could be useful for delivering combinations of cancer
therapeutics. The liposomes were coated with folate to facilitate cancer cell
targeting and loaded with Tarceva
in their hydrophobic regions and doxorubicin in their hydrophilic
regions. In mouse xenograft models of triple-negative breast cancer (TNBC)
and non-small cell lung cancer (NSCLC), the nanoparticles caused tumor
regression, whereas targeted, single-drug nanoparticles resulted in continued
tumor growth. In human TNBC and NSCLC cell lines, folate-targeted
liposomes loaded with doxorubicin or cisplatin
and various receptor
tyrosine kinase (RTK)
inhibitors generally showed greater cytotoxicity than liposomes containing
single drugs. Next steps could include evaluating the liposomal nanoparticles
for the delivery of additional combinations of cancer drugs.
Pharma Inc., Chugai
Pharmaceutical Co. Ltd. and Roche
market the small molecule epidermal
growth factor receptor (EGFR)
inhibitor Tarceva to treat liver cancer, pancreatic cancer and NSCLC.
Published online June 12, 2014
Patent application filed;
licensing status unavailable
Morton, S.W. et al. Sci.
Signal.; published online May 13, 2014;
Contact: Paula T. Hammond, Massachusetts Institute of
Technology, Cambridge, Mass.
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