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Disease models

Engineered bone marrow-on-a-chip system

An engineered bone marrow-on-a-chip system could be useful in screening drug candidates for hematopoietic toxicity. The microchip consists of an engineered bone and bone marrow construct grown in mice that is inserted into an in vitro microfluidic culture system. The engineered bone marrow on the microchip retained the composition of natural bone marrow and recapitulated features of the hematopoietic niche. It also showed responses to radiation exposure and granulocyte colony-stimulating factor (G-CSF; CSF3) that were similar to those of bone marrow in live mice. Next steps include developing a humanized version of the bone marrow-on-a-chip system.

SciBX 7(23); doi:10.1038/scibx.2014.687
Published online June 12, 2014

Patent application filed; licensing discussions under way with undisclosed parties

Torisawa, Y.-s. et al. Nat. Methods; published online May 4, 2014;
Contact: Donald E. Ingber, Harvard University, Cambridge, Mass.