Thursday, June 5, 2014
Publication and contact
Expansion of primitive, CD34+ cord blood cells with histone
Mouse and ex vivo
studies suggest HDAC inhibitors could be used to expand functional cord blood
stem cells for transplant. In serum-free cultures of CD34+ hematopoietic progenitor cells, the HDAC inhibitor valproic
acid (VPA) increased CD34+ cell numbers by 4.2-fold and multipotent CD34+ and thymus
cell antigen 1q (Thy1;
CD90)+ cell numbers by 144-fold compared with medium
alone. In immunodeficient mice, transplanted human CD34+ cells treated with VPA and primed with cytokines
showed greater engraftment than cells that were only primed with cytokines.
Next steps could include assessing the efficacy of the method for
replenishing all hematopoietic cell lineages in mice.
Published online June 5, 2014
Patent and licensing status
Chaurasia, P. et al. J.
Clin. Invest.; published online April 24, 2014;
Contact: Ronald Hoffman, The Tisch Cancer Institute, Icahn
School of Medicine at Mount Sinai, New York, N.Y.
Contact: Pratima Chaurasia, same affiliation as above
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