Thursday, June 5, 2014
Publication and contact
Expansion of CD19-specific
chimeric antigen receptor (CAR) T memory stem cells to improve adoptive T
Studies in patient samples
and mice suggest increasing the subpopulation of T memory stem cells could
help improve the efficacy of CAR-based T cell therapy. In populations of
transplanted CD19-specific CAR T cells, a high frequency of cells resembling
T memory stem cells correlated with increased expansion and persistence of
the CAR T cells. In ex vivo, cultured CAR T cells, IL-7
increased the population of the T memory stem cells compared with IL-2.
In tumor-bearing mice, adoptive therapy with IL-7- and IL-15-expanded CAR T
cells delayed disease progression and resulted in increased survival compared
with therapy using IL-2-expanded CAR T cells. Researchers did not disclose
next steps, which could include optimizing CAR T cell culturing conditions to
further boost the T memory stem cell subpopulation.
Published online June 5, 2014
Patent and licensing status
Yang, X. et al. Blood;
published online April 29, 2014;
Contact: Gianpietro Dotti, Baylor College of Medicine,
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]