Thursday, June 5, 2014
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Expansion of CD19-specific
chimeric antigen receptor (CAR) T memory stem cells to improve adoptive T
Studies in patient samples
and mice suggest increasing the subpopulation of T memory stem cells could
help improve the efficacy of CAR-based T cell therapy. In populations of
transplanted CD19-specific CAR T cells, a high frequency of cells resembling
T memory stem cells correlated with increased expansion and persistence of
the CAR T cells. In ex vivo, cultured CAR T cells, IL-7
increased the population of the T memory stem cells compared with IL-2.
In tumor-bearing mice, adoptive therapy with IL-7- and IL-15-expanded CAR T
cells delayed disease progression and resulted in increased survival compared
with therapy using IL-2-expanded CAR T cells. Researchers did not disclose
next steps, which could include optimizing CAR T cell culturing conditions to
further boost the T memory stem cell subpopulation.
Published online June 5, 2014
Patent and licensing status
Yang, X. et al. Blood;
published online April 29, 2014;
Contact: Gianpietro Dotti, Baylor College of Medicine,
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