Thursday, June 5, 2014
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Adoptive cell therapy using
mutation-specific, CD4+ T cells in epithelial cancer
A single-patient study
suggests adoptive cell therapy using tumor mutation-specific, CD4+ T cells could help treat epithelial cancer. Ex
vivo, patient dendritic cells were transfected with RNAs representing 26
different patient-specific cancer mutations identified via whole-exome
sequencing and then cocultured with patient tumor-infiltrating lymphocytes
(TILs). Patient CD4+ T cells specifically recognized dendritic cells
presenting an ErbB2
interacting protein (ERBB2IP)
antigen with an E805G mutation. In the patient, adoptive transfer of about 10
billion ERBB2IPE805G mutation-specific, CD4+ T cells led to tumor regression that peaked at 7
months and disease stabilization for about 13 months. Next steps include
evaluating mutations in additional cancers that would be recognized by T
cells and amenable for use in mutation-specific, CD4+ T cell therapy.
Published online June 5, 2014
Patent application filed;
licensing status unavailable
Tran, E. et al. Science;
published online May 9, 2014;
Contact: Steven A. Rosenberg, National Cancer Institute,
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