Thursday, June 5, 2014
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Fibrin hydrogel for
controlled and sustained delivery of recombinant VEGF
In vitro and mouse studies suggest a fibrin hydrogel that
provides controlled and sustained release of VEGF could help treat ischemia.
The fibrin hydrogel contains a fusion protein made up of the N terminus of
murine Vegf and an a2 plasmin inhibitor segment that binds fibrin plus a second
fusion protein made up of the fibrinolysis inhibitor aprotinin
and an a2 plasmin inhibitor segment. In immunodeficient
mice, subcutaneous injection of the fusion protein-containing hydrogel
resulted in stable release of Vegf over four weeks as it degraded. In two
rodent models of hind limb and wound-healing ischemia, intramuscular
injection of the fusion protein-containing hydrogel induced stable
angiogenesis and increased blood flow to ischemic tissues compared with
injection of an empty hydrogel. Next steps include repeating the ischemia
experiments in large-animal models.
Kuros Biosurgery AG has multiple
fibrin hydrogel-based products in Phase II or earlier testing to promote bone
repair or wound healing.
Published online June 5, 2014
Technology for binding
growth factors to fibrin patented; licensed to Kuros Biosurgery
Sacchi, V. et al. Proc.
Natl. Acad. Sci. USA; published online April 28, 2014;
Contact: Andrea Banfi, University of Basel, Basel,
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