Thursday, May 29, 2014
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small molecule probe to image tumor response to chemotherapy in vivo
Cell culture and mouse
studies have identified an apoptosis-sensing molecular probe that could be
used to image tumor response to treatment in vivo. A biocompatible,
caspase-sensitive fluorescent probe that self-assembles within cells after
caspase cleavage and thiol-mediated cyclization was identified. In cultured
tumor cell lines, staurosporine- or doxorubicin-induced
apoptosis led to a dose- and time-dependent increase in probe fluorescence
within cells compared with no treatment. In a mouse xenograft model of
cervical cancer, i.v. infusion of the probe plus doxorubicin led to greater
fluorescence within tumor cells than either infusion of the probe plus saline
or doxorubicin alone. Next steps include adapting the probe for PET or MRI
Staurosporine is a research reagent that acts as a pan-kinase inhibitor.
Doxorubicin is a generic chemotherapy drug.
Published online May 29, 2014
Patented; available for
Ye, D. et al. Nat. Chem.;
published online April 28, 2014;
Contact: Jianghong Rao, Stanford University, Stanford,
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