Thursday, May 29, 2014
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Human embryonic stem cell-derived
cardiomyocytes (hESC-CMs) to treat ischemia/reperfusion injury
Nonhuman primate studies
suggest hESC-CM transplantation could be used to treat ischemia/reperfusion
injury. In a nonhuman primate model of ischemia/reperfusion injury, delivery
of one billion hESC-CMs to the infarct site resulted in their engraftment in
the host animal heart and subsequent maturation and perfusion by blood
vessels over a period of three months. In animals that received the
transplant, the grafts showed electromechanical coupling with the heart, but
ventricular arrhythmias were observed for the first two weeks after the
transplant. Next steps could include conducting studies using larger numbers
of animals to determine the mechanisms leading to the arrhythmias and doing a
more detailed assessment of cardiac function.
Published online May 29, 2014
Patent and licensing status
Chong, J.J.H. et al.
Nature; published online April 30, 2014;
Contact: Charles E. Murry, University of Washington, Seattle,
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