Licensing status

Publication and contact information

Drug delivery

Paired liposomes for intracellular, ATP-inducible drug release

A paired liposome system for ATP-induced chemotherapy release could help treat cancers. The system uses a cell-penetrating, ATP-containing liposome plus a membrane fusion-promoting liposome containing an ATP-responsive DNA scaffold loaded with doxorubicin. In a mouse xenograft model of human breast cancer, intratumoral injection of both liposomes increased tumor growth inhibition compared with injection of the doxorubicin-containing liposome alone or free doxorubicin. Next steps include testing the liposome delivery system on larger animals and adapting it for the delivery of other drugs.

SciBX 7(21); doi:10.1038/scibx.2014.625
Published online May 29, 2014

Patent application filed; available for licensing

Mo, R. et al. Angew. Chem. Int. Ed.; published online April 24, 2014;
Contact: Zhen Gu, The University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, N.C.
Contact: Ran Mo, same affiliation as above