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Disease models

Mouse models of lung squamous cell carcinoma with inactivated serine/threonine kinase 11 (Stk11; Lkb1) and Pten (Mmac1; Tep1)

Mice with lung-specific inactivation of Lkb1 and Pten could be useful as models to evaluate therapeutic candidates for lung squamous cell carcinoma. The mice developed malignant nodules in the lung that showed squamous characteristics 30-40 weeks after inactivation of Lkb1 and Pten. In these mice, the histological and gene expression profile of the tumors recapitulated multiple hallmarks of human squamous cell carcinoma. Next steps could include evaluating the effect of various cancer therapies in the mouse model.

SciBX 7(21); doi:10.1038/scibx.2014.624
Published online May 29, 2014

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Xu, C. et al. Cancer Cell;
published online May 1, 2014;
Contact: Kwok-Kin Wong, Harvard Medical School, Boston, Mass.
Contact: Carla F. Kim, Boston Children's Hospital, Boston, Mass.
Contact: Peter S. Hammerman, Dana-Farber Cancer Institute, Boston, Mass.