Thursday, May 29, 2014
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Mouse models of lung
squamous cell carcinoma with inactivated serine/threonine
kinase 11 (Stk11;
Mice with lung-specific
inactivation of Lkb1 and Pten could be useful as models to
evaluate therapeutic candidates for lung squamous cell carcinoma. The mice
developed malignant nodules in the lung that showed squamous characteristics
30-40 weeks after inactivation of Lkb1 and Pten. In these mice,
the histological and gene expression profile of the tumors recapitulated
multiple hallmarks of human squamous cell carcinoma. Next steps could include
evaluating the effect of various cancer therapies in the mouse model.
Published online May 29, 2014
Patent and licensing status
et al. Cancer Cell;
published online May 1, 2014;
Contact: Kwok-Kin Wong, Harvard Medical School, Boston, Mass.
Contact: Carla F. Kim, Boston Children's Hospital, Boston,
Contact: Peter S. Hammerman, Dana-Farber Cancer Institute,
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