Thursday, May 22, 2014
Publication and contact
Assays & screens
(nPLEX) sensor for high throughput, label-free, quantitative analysis of
Patient sample studies
suggest an nPLEX sensor can help diagnose and/or monitor cancer treatment.
The nPLEX sensor is comprised of an array of nanopores in a metal film
functionalized with affinity ligands for specific proteins and a miniaturized
imaging system. Binding of affinity ligands to proteins on exosomes results
in a spectral shift. In ascites derived from patients with ovarian cancer, epithelial
cell adhesion molecule (EpCAM)
arrays detected more exosomes and higher levels of protein per exosome than
what was seen in ascites derived from patients with cirrhosis. Next steps
include performing large-scale proteomic analysis on exosomes.
Published online May 22, 2014
Patents on nPLEX device and
assays filed; available for licensing from Massachusetts General Hospital
Contact: Dan Castro, Massachusetts General Hospital, Boston,
Im, H. et al. Nat.
Biotechnol.; published online April 20, 2014;
Contact: Hakho Lee, Massachusetts General Hospital, Boston, Mass.
Contact: Ralph Weissleder, same affiliation as above
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]