Thursday, May 22, 2014
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Assays & screens
(nPLEX) sensor for high throughput, label-free, quantitative analysis of
Patient sample studies
suggest an nPLEX sensor can help diagnose and/or monitor cancer treatment.
The nPLEX sensor is comprised of an array of nanopores in a metal film
functionalized with affinity ligands for specific proteins and a miniaturized
imaging system. Binding of affinity ligands to proteins on exosomes results
in a spectral shift. In ascites derived from patients with ovarian cancer, epithelial
cell adhesion molecule (EpCAM)
arrays detected more exosomes and higher levels of protein per exosome than
what was seen in ascites derived from patients with cirrhosis. Next steps
include performing large-scale proteomic analysis on exosomes.
Published online May 22, 2014
Patents on nPLEX device and
assays filed; available for licensing from Massachusetts General Hospital
Contact: Dan Castro, Massachusetts General Hospital, Boston,
Im, H. et al. Nat.
Biotechnol.; published online April 20, 2014;
Contact: Hakho Lee, Massachusetts General Hospital, Boston, Mass.
Contact: Ralph Weissleder, same affiliation as above
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