Thursday, May 15, 2014
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Hydroxyprostaglandin dehydrogenase 15 NAD (HPGD;
expression as a biomarker of aspirin-associated decrease in
colorectal cancer risk
expression could help predict whether regular aspirin use will help decrease
colorectal cancer risk. In a study with 127,865 participants, regular aspirin
use was associated with decreased incidence of colorectal cancer in subjects
who had high HPGD expression in the colonic mucosa but not in subjects
who had low HPGD expression. Next steps include carrying out a
prospective clinical trial to determine whether levels of HPGD in patients
are a significant predictor of whether aspirin therapy can decrease recurrent
Published online May 15, 2014
Use of HPGD to select
individuals for treatment with aspirin patented; available for licensing
Fink, S.P. et al. Sci.
Transl. Med.; published online April 23, 2014;
Contact: Andrew T. Chan, Harvard Medical School, Boston,
Contact: Reiko Nishihara,
Dana-Farber Cancer Institute,
Contact: Sanford D. Markowitz, Case Western Reserve
University, Cleveland, Ohio
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