Thursday, May 15, 2014
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polysialyltransferase engineered to generate uniform polysaccharides for
In vitro studies suggest a bacterial polysialyltransferase
could be used to improve drug pharmacology. Pharmacological properties of
therapeutic proteins can be enhanced by attached polysialic acid, but
polysialyltransferases usually generate polysialic chains of varying lengths
because the enzyme retains its substrate for more than one catalytic cycle.
Mutational analysis of polysialyltransferase from Neisseria meningitidis
identified a point mutation that resulted in the enzyme releasing the
substrate after every catalytic cycle, allowing for control over chain
length. Next steps include investigating whether uniform polysialylation can
be obtained on clinically relevant proteins including interferon-a (IFNA;
Published online May 15, 2014
status not applicable
Keys, T.G. et al. Nat.
Chem. Biol.; published online April 13, 2014;
Contact: Rita Gerardy-Schahn, Hannover Medical School,
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