Thursday, May 15, 2014
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Assays & screens
Signature of 24 genes to
predict prostate cancer recurrence
identified a 24-gene panel that could help predict disease recurrence in
patients with prostate cancer. In 106 prostate tumor samples, RNA sequencing
led to the identification of a 24-gene signature that differentiated patients
at high and low risk of disease recurrence when combined with assessment of
clinical variables. In a validation dataset from 140 patients with prostate
cancer, assessing clinical variables together with the 24-gene panel resulted
in increased predictive capability of disease recurrence compared with
assessing clinical variables alone or in combination with a gene signature
from a panel of 31 cell-cycle progression genes. Next steps include
validating the biomarkers in a larger patient cohort.
Published online May 15, 2014
Patent application filed;
available for licensing
Long, Q. et al. Cancer
Res.; published online April 8, 2014;
Contact: Carlos S. Moreno, Emory University,
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