Thursday, May 15, 2014
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Assays & screens
profiling by deep sequencing (CAPP-seq) to characterize cancer using blood
and analysis of circulating tumor DNA using CAPP-seq could help diagnose
cancer and monitor response to therapy. CAPP-seq quantifies and identifies
known mutations in circulating tumor DNA. In tumor samples from 13 patients
with non-small cell lung cancer (NSCLC) and samples from 5 healthy controls,
CAPP-seq detected cancer with 96% specificity, and quantification of plasma
circulating tumor DNA levels correlated with tumor volume. In repeated
sampling of three patients throughout treatment, circulating tumor DNA
quantity correlated with tumor volume and better predicted residual disease
and recurrence than imaging. Next steps could include validating the method
in additional patients.
Published online May 15, 2014
Patent and licensing status
Newman, A.M. et al. Nat.
Med.; published online April 6, 2014;
Contact: Maximilian Diehn, Stanford University, Stanford,
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