Thursday, May 8, 2014
Publication and contact
Mouse model of early T cell
precursor acute lymphoblastic leukemia (ETP-ALL) with IL-7
A mouse model of ETP-ALL
could help identify new therapeutics for the disease. In immature thymocytes,
expression of a mutant form of CD127 found in pediatric cases of ETP-ALL
blocked differentiation of thymocytes early in development. In irradiated
mice, transplantation of thymocytes expressing mutant Cd127, but not
wild-type Cd127, caused lethal leukemia with similar gene expression patterns
as the human pediatric cancers. In the ETP-ALL mouse model, the Janus
increased survival compared with vehicle. Next steps could include using the
model to identify other therapeutics for ETP-ALL.
Incyte Corp. and
market Jakafi to treat myeloproliferative disorder.
Published online May 8, 2014
Patent and licensing status
Treanor, L.M. et al. J.
Exp. Med.; published online March 31, 2014;
Contact: Brian P. Sorrentino, St. Jude Children's Research
Hospital, Memphis, Tenn.
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]