Thursday, May 1, 2014
Publication and contact
Solute carrier family 12
potassium-chloride transporter member 2 (SLC12A2;
markers for schizophrenia
Genetic profiling studies
suggest assessing variation in NKCC1 expression could help predict
schizophrenia risk. NKCC1 is expressed as two alternative splice
variants-NKCC1a and NKCC1b-and
as an ultra-short transcript. Sequencing and analysis of postmortem brain
tissue samples showed that schizophrenia patients had lower expression of the
NKCC1b and ultra-short transcripts than controls without psychiatric
disorders. The rs3087889 SNP in NKCC1 was associated with decreased NKCC1b
expression and increased risk of schizophrenia. Next steps could include
validating the various NKCC1-based markers in larger patient cohorts.
Published online May 1, 2014
Patent and licensing status
Morita, Y. et al. J.
Neurosci.; published online April 2, 2014;
Contact: Thomas M. Hyde, Lieber Institute for Brain
Development, Baltimore, Md.
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