Thursday, May 1, 2014
Publication and contact
Solute carrier family 12
potassium-chloride transporter member 2 (SLC12A2;
markers for schizophrenia
Genetic profiling studies
suggest assessing variation in NKCC1 expression could help predict
schizophrenia risk. NKCC1 is expressed as two alternative splice
variants-NKCC1a and NKCC1b-and
as an ultra-short transcript. Sequencing and analysis of postmortem brain
tissue samples showed that schizophrenia patients had lower expression of the
NKCC1b and ultra-short transcripts than controls without psychiatric
disorders. The rs3087889 SNP in NKCC1 was associated with decreased NKCC1b
expression and increased risk of schizophrenia. Next steps could include
validating the various NKCC1-based markers in larger patient cohorts.
Published online May 1, 2014
Patent and licensing status
Morita, Y. et al. J.
Neurosci.; published online April 2, 2014;
Contact: Thomas M. Hyde, Lieber Institute for Brain
Development, Baltimore, Md.
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]