Approach

Summary

Licensing status

Publication and contact information

Imaging

Combined use of luminescence imaging and MRI for real-time, in vivo, quantitative monitoring of drug release

A combined strategy using luminescence imaging and MRI could be useful for real-time, quantitative monitoring of drug release
in vivo. Nanoparticles designed to release their payload in response to excitation with near-infrared light were loaded with doxorubicin. In a human cancer cell line and in zebrafish treated with the doxorubicin-loaded nanoparticles, the combined imaging strategy using luminescence imaging and MRI enabled real-time monitoring and quantification of doxorubicin release from the nanoparticles. Ongoing work includes using the approach to perform real-time monitoring of drug release in larger animal models, including rabbits and canines.

SciBX 7(17); doi:10.1038/scibx.2014.506
Published online May 1, 2014

Unpatented; licensing status not applicable

Liu, J. et al. Angew. Chem. Int. Ed.; published online March 25, 2014;
doi:10.1002/anie.201400900
Contact: Jianlin Shi, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, China
e-mail:

jlshi@mail.sic.ac.cn
Contact: Wenbo Bu, same affiliation as above
e-mail:

wbbu@mail.sic.ac.cn