Thursday, May 1, 2014
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Ex vivo wingless-type
MMTV integration site family member 7A (WNT7A)
treatment of myogenic cells prior to muscle cell transplantation to enhance
both fusion with myofibrils and muscle function
Cell culture and mouse
studies suggest ex vivo treatment with WNT7A could improve stem cell
therapies for muscular dystrophies. In culture, WNT7A increased migration of
satellite cell-derived mouse primary myoblasts compared with vehicle or WNT3A.
In mice, ex vivo WNT7A increased migration of transplanted primary
mouse myoblasts compared with vehicle. In a mouse model of muscular
dystrophy, transplantation of human or mouse myogenic cells treated ex
vivo with WNT7A improved muscle function and increased their engraftment,
dispersal and fusion with myofibrils compared with transplantation of cells
treated with WNT3A or vehicle. Next steps could include production of
Fate Therapeutics Inc.'s
WNT7A analog FT301
is in preclinical development to treat muscular dystrophy.
Published online May 1, 2014
Patented; licensed to Fate
Bentzinger, C.F. et al.
J. Cell Biol.; published online April 7, 2014;
Contact: Michael A. Rudnicki, Ottawa Hospital Research
Institute, Ottawa, Ontario, Canada
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