Thursday, April 24, 2014
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Assays & screens
proficiency score to guide the use of DNA-damaging cancer therapies
Studies in patient tumor
samples have identified a four-gene expression signature that could help
determine prognosis and guide treatment for various cancers. The signature
quantifies the efficiency of DNA repair pathways and is based on the mRNA
levels of four DNA repair-associated genes-RAP1
interacting factor homolog (RIF1),
repair complementing defective repair in Chinese hamster cells 5
binding protein (PARPBP; PARI)
In tumors from patients with non-small cell lung cancer (NSCLC) treated with
surgery plus DNA-damaging, platinum-based chemotherapy, a low signature score
was associated with increased patient survival. Next steps include further
characterizing the molecular responses associated with downregulation of the
Published online April 24, 2014
application filed; available for licensing
Pitroda, S.P. et al.
Sci. Transl. Med.; published online March 26, 2014;
Contact: Phillip P. Connell, The University of Chicago,
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