Thursday, April 24, 2014
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Assays & screens
Ex vivo model of HIV latency to screen latency-reversing
An ex vivo model of
latent HIV in patient T cells could help predict clinical efficacy of
latency-reversing agents. In a coculture of
T cells from patients latently infected with HIV and healthy controls,
latency-reversing compounds previously shown to be effective in vitro
failed to induce spreading of the virus to noninfected cells, indicating that
they do not reverse viral latency ex vivo. In latently infected cells
from patients on antiretroviral therapy, all tested compounds failed to
reverse latency as measured by HIV mRNA transcription except bryostatin-1,
which is toxic in vivo. Next steps include identifying new agents or
combinations that reactivate latent HIV in patient cells.
Published online April 24, 2014
status not applicable
Bullen, C.K. et al. Nat.
Med.; published online March 23, 2014;
Contact: Robert F. Siliciano, The Johns Hopkins University
School of Medicine, Baltimore, Md.
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