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MicroRNA-155 (miR-155) as a predictive marker of breast cancer response to radiation therapy

In vitro and mouse studies suggest miR-155 levels could help predict breast cancer response to radiation therapy. In two independent cohorts of patients with triple-negative breast cancer that received chemotherapy and radiation therapy, elevated miR-155 expression was associated with increased overall survival. In a human triple-negative breast cancer cell line, expression of miR-155 decreased levels of RAD51 homolog (RAD51), a factor involved in DNA repair, and increased sensitivity to ionizing radiation compared with expression of a scrambled oligonucleotide. Next steps include validating the results in larger cohorts.

SciBX 7(15); doi:10.1038/scibx.2014.445
Published online April 17, 2014

Findings unpatented; licensing status not applicable

Gasparini, P. et al. Proc. Natl. Acad. Sci. USA; published online March 10, 2014;
Contact: Carlo M. Croce, The Ohio State University, Columbus, Ohio