Thursday, April 10, 2014
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Enhanced antigen-specific T
cell activation using nanoscale artificial antigen-presenting cells (aAPCs)
in a magnetic field
In vitro and mouse studies suggest magnetic-field culturing
methods could increase activation of antigen-specific T cells by nanoscale
aAPCs. In T cells cultured with nanoscale aAPCs, exposure to a magnetic field
induced aAPC aggregation to increase T cell receptor cluster size, which led
to increased T cell expansion and activation compared with no exposure to a
magnetic field. In mice with subcutaneous melanoma tumors, adoptive transfer
of tumor-specific T cells activated by aAPCs in a magnetic field caused decreased
tumor growth compared with adoptive transfer of cells cultured without the
magnetic field. Next steps include developing GMP-grade materials for use in
Published online April 10, 2014
Patent applications filed;
exclusively licensed to NexImmune Inc.
for immune regulation; available for licensing in indications other than
Perica, K. et al. ACS
Nano; published online Feb. 24, 2014;
Contact: Jonathan P. Schneck, The Johns Hopkins University
School of Medicine, Baltimore, Md.
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