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Enhanced antigen-specific T cell activation using nanoscale artificial antigen-presenting cells (aAPCs) in a magnetic field

In vitro and mouse studies suggest magnetic-field culturing methods could increase activation of antigen-specific T cells by nanoscale aAPCs. In T cells cultured with nanoscale aAPCs, exposure to a magnetic field induced aAPC aggregation to increase T cell receptor cluster size, which led to increased T cell expansion and activation compared with no exposure to a magnetic field. In mice with subcutaneous melanoma tumors, adoptive transfer of tumor-specific T cells activated by aAPCs in a magnetic field caused decreased tumor growth compared with adoptive transfer of cells cultured without the magnetic field. Next steps include developing GMP-grade materials for use in humans.

SciBX 7(14); doi:10.1038/scibx.2014.416
Published online April 10, 2014

Patent applications filed; exclusively licensed to NexImmune Inc. for immune regulation; available for licensing in indications other than immunology

Perica, K. et al. ACS Nano; published online Feb. 24, 2014;
Contact: Jonathan P. Schneck, The Johns Hopkins University School of Medicine, Baltimore, Md.