Thursday, April 10, 2014
Publication and contact
Pituitary ablation of estrogen
receptor expression as a mouse model for ovarian cancer
A genetic mouse model for
estrogen-dependent ovarian cancer could be used to study disease progression
and evaluate therapeutic candidates. In the mice, progesterone
receptor-driven Cre recombinase was used to knock out
estrogen receptor expression in the anterior pituitary. The resulting mice
showed disruption of the hypothalamic-pituitary-ovarian hormonal axis,
elevated estrogen production in ovaries, emergence of ovarian tumors and
oncogenic transformation of ovarian surface epithelial cells. In the ovarian
tumor-bearing mice, treatment with the aromatase
over 3 months decreased tumor volume by 60% compared with a sham treatment.
Next steps could include using the model to study drug interactions.
Published online April 10, 2014
Patent and licensing status
Laws, M.J. et al. PLoS
Genet.; published online March 6, 2014;
Contact: Indrani C. Bagchi, University of Illinois at
Urbana-Champaign, Urbana, Ill.
Contact: Milan K. Bagchi, same affiliation as above
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