Thursday, April 10, 2014
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Assays & screens
magnetic beads for isolation of circulating tumor cells (CTCs)
Magnetic beads tagged with
polymerized antibodies or antibody-like molecules could help capture CTCs for
cancer research purposes. A method of forming isopeptide bonds between
peptide-tagged proteins enabled synthesis of polymeric chains of
antibody-like molecules targeting epidermal
growth factor receptor 1 (EGFR1;
In cultures of human breast cancer cell lines expressing HER1 or in blood
samples spiked with HER2+ breast cancer
cells, magnetic beads tagged with the polymerized antibody-like molecules
captured cells better than magnetic beads tagged with monomeric antibody-like
molecules. Planned work includes using the technology to capture CTCs from
patients with breast cancer enrolled in a clinical trial of an undisclosed
Published online April 10, 2014
Patent application filed by
University of Oxford
for method of isopeptide bond formation; available for licensing
Fierer, J.O. et al.
Proc. Natl. Acad. Sci. USA; published online March 17, 2014;
Contact: Mark Howarth, University of Oxford, Oxford, U.K.
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