Thursday, April 10, 2014
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Assays & screens
Nanoparticles for in
vivo detection of drug-induced hepatotoxicity
Mouse studies suggest
semiconducting polymer nanoparticles (SPNs) could be used for real-time in
vivo monitoring of drug-induced hepatotoxicity. SPNs were generated
containing a liver-targeting galactose residue, a chemiluminescent
substrate and a fluorescent sensor that produces signals when detecting
reactive oxygen species (ROS) and reactive nitrogen species (RNS)
simultaneously. In mice, the SPNs detected ROS and RNS induced by toxic doses-but
not by subtoxic doses-of acetaminophen or isoniazid
earlier than histopathological changes occurred. Next steps include testing
toxicity of other small molecules and virus particles (see Toxic assests, page 8).
Published online April 10, 2014
Patent application filed;
available for licensing
Shuhendler, A.J. et al.
Nat. Biotechnol.; published online
March 23, 2014;
Contact: Jianghong Rao, Stanford University School of
Medicine, Stanford, Calif.
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