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Assays & screens

Nanoparticles for in vivo detection of drug-induced hepatotoxicity

Mouse studies suggest semiconducting polymer nanoparticles (SPNs) could be used for real-time in vivo monitoring of drug-induced hepatotoxicity. SPNs were generated containing a liver-targeting galactose residue, a chemiluminescent substrate and a fluorescent sensor that produces signals when detecting reactive oxygen species (ROS) and reactive nitrogen species (RNS) simultaneously. In mice, the SPNs detected ROS and RNS induced by toxic doses-but not by subtoxic doses-of acetaminophen or isoniazid earlier than histopathological changes occurred. Next steps include testing toxicity of other small molecules and virus particles (see Toxic assests, page 8).

SciBX 7(14); doi:10.1038/scibx.2014.408
Published online April 10, 2014

Patent application filed; available for licensing

Shuhendler, A.J. et al. Nat. Biotechnol.; published online
March 23, 2014;
Contact: Jianghong Rao, Stanford University School of Medicine, Stanford, Calif.