Thursday, April 3, 2014
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Fluorescent antibodies to
necrosis factor (mTNF) as a predictive biomarker for
against mTNF could provide an in vivo molecular diagnostic for
predicting response to anti-TNF treatment in Crohn's disease. In patients
with Crohn's disease not treated with anti-TNF therapy, live endoscopic
imaging of gut mucosa with fluorescently labeled Humira
an anti-TNF antibody, identified mTNF-expressing intestinal cells. High
numbers of mTNF-expressing cells correlated with clinical response to
subsequent anti-TNF antibody therapy, and low numbers of mTNF-expressing
cells correlated with lack of clinical response. Next steps include
comparable studies in ulcerative colitis and multicenter studies to test a
larger population of patients with Crohn's disease.
Humira is marketed by AbbVie Inc. to treat
several autoimmune diseases.
Published online April 3, 2014
Patent filed by the University
of Erlangen-Nuremberg; unavailable for licensing
Atreya, R. et al. Nat.
Med.; published online Feb. 23, 2014;
Contact: Markus F. Neurath, University of Erlangen-Nuremberg,
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