Thursday, April 3, 2014
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Multiplexed ion beam
imaging (MIBI) for detection of up to 100 target proteins in clinical samples
Imaging studies suggest
MIBI could simultaneously detect up to 100 antigen targets for clinical
diagnostics. MIBI involves incubation of biological samples with antibodies
coupled to lanthanides, which release secondary ions when exposed to an ion
beam. The ions are detected by a magnetic sector mass spectrometer that
analyzes each isotope and measures levels of each target. In peripheral blood
mononuclear cells, staining with several coupled antibodies generated signals
with intensities similar to those for mass spectrometry. In formalin-fixed,
paraffin-embedded human breast tumor specimens, MIBI simultaneously and
quantitatively detected 10 antigen labels. Next steps include prototype
construction and validation.
Published online April 3, 2014
Patent application filed;
available for licensing
Angelo, M. et al. Nat.
Med.; published online March 2, 2014;
Contact: Garry P. Nolan, Stanford University,
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