Thursday, April 3, 2014
Publication and contact
Multiplexed ion beam
imaging (MIBI) for detection of up to 100 target proteins in clinical samples
Imaging studies suggest
MIBI could simultaneously detect up to 100 antigen targets for clinical
diagnostics. MIBI involves incubation of biological samples with antibodies
coupled to lanthanides, which release secondary ions when exposed to an ion
beam. The ions are detected by a magnetic sector mass spectrometer that
analyzes each isotope and measures levels of each target. In peripheral blood
mononuclear cells, staining with several coupled antibodies generated signals
with intensities similar to those for mass spectrometry. In formalin-fixed,
paraffin-embedded human breast tumor specimens, MIBI simultaneously and
quantitatively detected 10 antigen labels. Next steps include prototype
construction and validation.
Published online April 3, 2014
Patent application filed;
available for licensing
Angelo, M. et al. Nat.
Med.; published online March 2, 2014;
Contact: Garry P. Nolan, Stanford University,
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]