Thursday, April 3, 2014
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Bioluminescent mouse model
of HPV+ oral tumors to track the effect of therapeutics
A bioluminescent mouse
model of HPV+ oral tumors could help evaluate potential
therapeutic candidates. In mice with inducible expression of the HPV
oncogenes E6 transforming protein (human
transforming protein (human
and luciferase, oncogenic K-Ras
expression in the epithelia induced the development of oral tumors with
enhanced bioluminescence that correlated with tumor growth. In the mouse
or image-guided radiotherapy induced tumor regression and decreased
bioluminescence at least threefold compared with vehicle or no irradiation.
Next steps could include using the model to test preclinical therapeutic
Rapamycin is a generic small molecule inhibitor of mammalian
target of rapamycin (mTOR;
Published online April 3, 2014
Patent and licensing status
Zhong, R. et al. Cancer
Res.; published online Feb. 13, 2014;
Contact: Michael Spiotto, The University of Chicago,
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