Thursday, March 20, 2014
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macrophages as diagnostic markers for metastasizing tumors
Human sample studies
suggest detection of circulating giant macrophages could be used to predict
solid tumor metastasis. In blood samples from a cohort of 79 patients with
breast, prostate or pancreatic cancer, a low-pressure filtration system with
precision microfilters isolated cancer-associated, macrophage-like cells
(CAMLs) with giant cellular morphology and large, atypical nuclei in 83%-97%
of the samples. CAMLs were positive for markers from engulfed cancer cells
and markers from angiogenic endothelial cells, and in 10% of the cases the
cells were associated with circulating tumor cells. Next steps include
identifying clinical applications for CAML measurements such as assessing
tumor responses to specific therapy.
Creatv MicroTech Inc.
markets the CellSieve microfiltration assay to isolate CAMLs.
Published online March 20, 2014
application filed; available for licensing
Adams, D.L. et al. Proc.
Natl. Acad. Sci. USA; published online Feb. 18, 2014;
Contact: Daniel L. Adams, Creatv MicroTech Inc., Rockville, Md.
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