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Circulating giant macrophages as diagnostic markers for metastasizing tumors

Human sample studies suggest detection of circulating giant macrophages could be used to predict solid tumor metastasis. In blood samples from a cohort of 79 patients with breast, prostate or pancreatic cancer, a low-pressure filtration system with precision microfilters isolated cancer-associated, macrophage-like cells (CAMLs) with giant cellular morphology and large, atypical nuclei in 83%-97% of the samples. CAMLs were positive for markers from engulfed cancer cells and markers from angiogenic endothelial cells, and in 10% of the cases the cells were associated with circulating tumor cells. Next steps include identifying clinical applications for CAML measurements such as assessing tumor responses to specific therapy.
Creatv MicroTech Inc. markets the CellSieve microfiltration assay to isolate CAMLs.

SciBX 7(11); doi:10.1038/scibx.2014.330
Published online March 20, 2014

Patent application filed; available for licensing

Adams, D.L. et al. Proc. Natl. Acad. Sci. USA; published online Feb. 18, 2014;
Contact: Daniel L. Adams, Creatv MicroTech Inc., Rockville, Md.