Thursday, March 20, 2014
Publication and contact
Müller glia cells as a
source for regenerative retinal neuronal cell types
In vitro and mouse studies suggest Müller glia cells can be
used to generate transplantable retinal progenitor cells for treating damaged
or degenerating retinas. In specific cell culture conditions, p53-/-
Müller glia could be induced to proliferate, convert into Müller glia-derived
progenitor-like cells (MRPs) expressing retinal progenitor markers and
further differentiate into cone and rod photoreceptors. In mice, p53-/-
MRPs injected into retinal tissue engrafted and differentiated into
photoreceptors and retinal ganglion cells, which are important for
transmission of visual information from photoreceptors to different brain
regions. Next steps include developing retinal differentiation protocols for
wild-type mouse Müller glia cells.
Published online March 20, 2014
Patent and licensing status
Zhao, J.J. et al. J.
Biol. Chem.; published online Feb. 12, 2014;
Contact: Kang Zhang, University of California, San Diego, La
Contact: Jack Jiagang Zhao, same affiliation as above
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