Thursday, March 13, 2014
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markers for paper-based detection of disease in urine samples
Mouse studies suggest
nanoparticles coated with protease-sensitive peptides that release biomarkers
into urine can be used with paper-based assays to diagnose colorectal cancer
and thrombosis. In mouse models of thrombosis or colorectal cancer, i.v. infused
thrombin- or matrix metalloprotease-sensitive
nanoparticles coated with reporter peptides underwent cleavage in blood clots
or tumors, respectively, to release the reporter molecules, which were
concentrated in urine. The reporters were detectable in urine samples with
ELISA and a paper-based lateral flow assay. In mice, the paper-based assay
distinguished between thrombotic and control animals with 92% accuracy and
between animals with and without subcutaneous colorectal tumors with 90%
accuracy. Next steps include developing similar systems for detection of
prostate cancer and for early detection of liver cancer metastasis.
Published online March 13, 2014
Patent applications filed
covering material formulation of synthetic biomarkers, urinary analysis and
companion paper tests; unavailable for licensing
Warren, A.D. et al.
Proc. Natl. Acad. Sci. USA; published online Feb. 24, 2014;
Contact: Sangeeta N. Bhatia, Massachusetts Institute of
Technology, Cambridge, Mass.
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