Thursday, March 13, 2014
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Lymph node-targeting cancer
Mouse studies suggest
albumin-binding DNA and peptide vaccines could help stimulate antitumor
immunity in lymph nodes to help treat cancer. SAR studies defined a set of
design rules for vaccines consisting of toll-like
receptor 9 (TLR9)-binding
CpG oligonucleotides or polyethylene glycol (PEG)-linked immunogenic peptides
and lymph node-targeting, lipophilic, albumin-binding tails. In mouse models
of melanoma and cervical cancer, antigenic peptide conjugates in combination
with albumin-targeting CpG increased antigen-specific CD8+ T cell numbers in sentinel lymph nodes and
decreased tumor growth compared with unmodified CpG in combination with
unconjugated antigenic peptides. Ongoing work includes testing potential
vaccine formulations in genetically engineered mouse models of cancer and
combining this vaccination strategy with other immunomodulatory therapies (see
guide to the lymph node, page 9).
Published online March 13, 2014
Patent application filed
covering chemical structure and design of the lymph node-targeting materials;
available for licensing
Liu, H. et al. Nature;
Feb. 16, 2014;
Contact: Darrell J. Irvine, Massachusetts Institute of
Technology, Cambridge, Mass.
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